Ameku Takao is a genius doctor with a knack for solving all kinds of difficult cases. When a man with blue blood is brought to Tenikai General Hospital—where Takao is the vice-director—after having his leg bitten off by a large beast, she starts investigating the intriguing case with the aid of her colleague, Takanashi.

Takao comes to the conclusion that the "large beast" responsible for severing the man's leg was, in fact, a Tyrannosaurus Rex. Following this shocking deduction, the case rapidly develops, and she and her crew head to the place where they hope to get answers to the remaining mystery of the victim's blue blood.

"Do you believe a video can be cursed?" A girl walks in front of a train after watching a particular video and is subsequently admitted to a psych ward. Takao is the only one who believes her twin sister when she says it wasn't a suicide attempt but the result of watching a cursed video, and the genius doctor sets about investigating.

"All who desecrate my grave shall be cursed to die." A university research team examining a grave reportedly linked to renowned onmyoji, Ashiya Doman, have started complaining about not feeling well, one after another. Takao is asked to investigate, but the case takes an unexpected turn.

Takao's diagnosis seems to solve Enzo's Curse. However, due to a mysterious death by fire, the investigation is right back at square one.

Despite another occurrence of the mysterious spontaneous human combustion phenomenon, the suspect arrested denies any involvement in either case.

Takao gets sued for malpractice! The hospital director uses the lawsuit to push for the disbandment of the Department of Investigative Pathology.

Several hospital staff report an angel in one room, and a pediatrician asks Takao for help with three children.